George, nice meeting you!
I suppose if one can equate our "lost conscience state" to sinning as compared to one sinning from his being "ignorant of the law", then I believe ignorance or being non conscience of the law of God is no excuse for sinning against God. IOW - if a person's conscience allows him to sin without him knowing it is a sin, he is still guilty of that sin, whether or not he is under the influence of a mind altering drug, a mental disease or whatever. Check out the O/T verses in Leviticus 4:13, 4:27 & 5:17.
Jesus gives an example in Luke 12:47,48 that someone who is ignorant in good faith is worthy of "stripes" but will receive less than the one who willfully sinned: "And that servant, which knows his lord's will, and prepared not himself, neither did according to his will, shall be beaten with many stripes. But he that knew not, and did commit things worth of stripes, shall be beaten with few stripes. For unto whomsoever much is given....".
In short - I believe ones who's conscience is seared or is ignorant of God's commandments does not free him from the penalty of transgression and will be chastised in this life - and if not in this life - will be judged accordingly in the coming Kingdom Age.