2 Timothy 3:1-5 (KJV)
3 This know also, that in the last days perilous times shall come.
2 For men shall be lovers of their own selves, covetous, boasters, proud, blasphemers, disobedient to parents, unthankful, unholy,
3 Without natural affection, trucebreakers, false accusers, incontinent, fierce, despisers of those that are good,
4 Traitors, heady, highminded, lovers of pleasures more than lovers of God;
5 Having a form of godliness, but denying the power thereof: from such turn away.
These conditions can be found globally, with specifics to many to number, but two human practices I find especially horrific. The first is human trafficking, which is practiced globally, and involves adults and children. This industry brings in more money than drugs ever could. The second is abortion, now legal in over 60% of the world.
I'm certain these human negative conditions affect everything pertaining to life on this planet, and would eventually be conducive to our own destruction, if we were left to our own devices.